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American Nobel laureate in medicine hopes to illuminate the brain
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Tens of thousands expected in Paris for high school protests
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Trump approves firing squad for convicted US military base shooter
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AI borrowing binge rattles US markets
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Grappling with 'homework scams,' US universities shun AI detectors
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Young Canadians sue government over alleged climate failures
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Separatists win Quebec election in test for Canada PM
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White Sox down Guardians to take 2-0 series lead
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Leaders visit Pacific atoll at frontline of climate change
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NHL record-breaker Ovechkin says current season will be his last
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Yemen's Houthis claim striking Riyadh airport, other Saudi sites
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France roar back in Nations League as Italy beat Turkey
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Best-selling British author Jeffrey Archer dies aged 86
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Messi readies for final farewell in Argentina send-off
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Military plane crash kills 32 in Nigeria
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Esposito seals Italy win over Turkey in Nations League
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Olise powers France to win over Belgium in Nations League
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Russia downplays plague reports as Trump offers US help
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High-flying Blazy turns to birdlife at Chanel
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Trump says US moved bombers from UK base after 'threats'
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Riyadh's allies pledge troops as Yemen, Saudi Arabia attack Houthis
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Brazilian stocks surge to record after Bolsonaro election lead
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Clashes erupt outside Kosovo parliament over war crimes court
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Leaders to visit Pacific atoll at frontline of climate change
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Milan's Saelemaekers suffers ankle setback, faces lengthy spell out
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ICC gives more details about arrest warrants for Taliban ministers
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Rubio arrives in Iceland to push for greater US presence in Arctic
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Nigeria's Tinubu confirms 32 dead after military plane crash
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Putin allows Italy's UniCredit to sell part of Russian business
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'Reckless' AI firms can't control models, says whistleblower
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Djokovic into China Open final as Medvedev out for hitting fan with ball
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Switching on brain cells: the Nobel-winning science of optogenetics
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ICC unseals arrest warrants for Taliban education ministers
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Quebec votes as separatist surge poses test for Canada PM
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Modric hopes fans back Croatia against Spain after England shame
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Euro slides as concerns about French debt mount
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Bolsonaro rides right-wing surge into Brazil's election runoff
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Former Trump press secretary Leavitt joins Fox News
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Turkey blocks X account of British reporter
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Djokovic advances to China Open final as Medvedev out for hitting fan with ball
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Ukraine says using AI robot guns to shoot down new Russian drones
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Disgraced former US House speaker dies at 84
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At Oct 7 memorial, Netanyahu says will be no Hamas rule in Gaza
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Euro slides as worries about French debt grow
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Ukraine blames Russia for deadly sinking of Turkish ship in Black Sea
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US withdraws all bomber aircraft from UK airbase
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UN rights council slams Taliban's 'oppression' of women
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Drone hits Ethiopia IDP camp as fears grow of regional war
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Norway eyes partial ban of smart glasses
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US-German trio wins medicine Nobel for illuminating the brain
Stocks mixed as rate cut bets are trimmed, US vote in focus
Equities diverged Wednesday after another unremarkable day on Wall Street, where rising bond yields and comments from Federal Reserve officials dampened expectations for US interest rate cuts.
A global rally that has seen several markets hit multiple records -- particularly in New York -- appears to have run out of gas as traders assess the US central bank's plans in the wake of forecast-topping economic data and ahead of a tight presidential election.
They are also keeping tabs on Beijing, hoping for more measures to reignite growth after a slew of stimulus over the past month, while geopolitical tensions helped push safe-haven gold to another peak.
Bets on another bumper 50-basis-point rate cut at the Fed's next meeting have dwindled following a recent spate of data showing the world's top economy in rude health and the labour markets resilient.
A number of key members of the bank's policy board have said that while they are in favour of further reductions, they did not want to go too quickly.
That comes as markets eye a possible Donald Trump victory in next month's presidential polls, which observers warn could see him implement tax cuts and impose tariffs that could restoke inflation.
Treasury yields are at their highest since July.
"Investors are navigating a tangled web of geopolitical tensions in the Middle East, a Federal Reserve turning out less dovish than expected, and the sudden reawakening of the 'Trump Trade'," said Stephen Innes, managing partner at SPI Asset Management.
"The latter has shaken the bond market, forcing some bond traders to pull their heads out of the sand as real jitters emerge about the fiscal landscape post-election."
The Dow and S&P 500 both fell for a second straight day on Wall Street, having ended at fresh peaks Friday, though the Nasdaq ticked higher.
Asian markets fluctuated.
Tokyo ended down despite a weaker yen caused by a softening of expectations on US rate cuts. The Japanese unit is sitting at more than 152 per dollar, levels not seen since July.
However, shares in Tokyo Metro rocketed 45 percent on their debut after its government owners raised $2.3 billion in Japan's biggest initial public offering for six years.
Wellington, Manila, Jakarta and Taipei also fell.
Hong Kong climbed more than one percent, building on the healthy run-up enjoyed in the wake of China's raft of economic support measures.
Shanghai also advanced, along with Sydney, Seoul, Singapore and Mumbai.
London edged up but Paris and Frankfurt dipped.
Gold touched a new record of $2,755.47 on the uncertainty over the US vote as well as fears about the Middle East crisis as Israel plots its retaliation against Iran after this month's missile barrage by Tehran.
The geopolitical concerns offset the rowing back of US rate-cut bets that had helped propel bullion higher in recent months.
Oil ticked down after surging more than two percent Tuesday in reaction to Chinese authorities lifting import quotas on independent oil refineries from next year in a sign growth may be recovering.
- Key figures around 0810 GMT -
Tokyo - Nikkei 225: DOWN 0.8 percent at 38,104.86 (close)
Hong Kong - Hang Seng Index: UP 1.3 percent at 20,760.15 (close)
Shanghai - Composite: UP 0.5 percent at 3,302.80 (close)
London - FTSE 100: UP 0.2 percent at 8,322.37
Euro/dollar: DOWN at $1.0786 from $1.0800 on Tuesday
Pound/dollar: DOWN at $1.2971 from $1.2977
Dollar/yen: UP at 152.36 yen from 151.02 yen
Euro/pound: UP at 83.16 pence from 83.14 pence
West Texas Intermediate: DOWN 0.7 percent at $71.27 per barrel
Brent North Sea Crude: DOWN 0.6 percent at $75.58 per barrel
New York - Dow: FLAT at 42,924.89 (close)
J.Pereira--PC